HIV Infection Increases Risk for Non-AIDS Cancer
16 Ianuarie 2010
In an article published on December 30th by Reuters Health Information (New York) and overtaken by Medscape it is stated that people living with HIV have an increased risk of different types of cancer incidence, which under normal conditions are unassociated to the Acquired immune deficiency syndrome (AIDS).
In general, AIDS, as a final stage of the HIV infection, determines the incidence of some types of malignity, which in a static mode are acknowledged to be traditionally associated to AIDS. The article and the researches, whose results had been recently issued, make a reference to some types of cancer that normally are not associated to the final stage of the HIV infection.
The published data in the article are based on a meta-analysis made by dr. Meredith Shiels and her colleagues from Johns Hopkins Bloomberg School of Health in Baltimore. The analysis is made considering the 18 studies including 625.716 HIV positive people who developed 4.797 types of non-AIDS cancers.
This analysis, which was run for many years, confirmed that the patients with HIV infection present an increased risk to develop non-AIDS malign diseases: compared to the representative patterns of the general population, the standard incidence rates were higher by 28 % for anal cancer, by 5,6 % for hepatic cancer and by 11 % higher for the Hodgkin Lymphoma. The cancers associated to smoking also registered a higher incidence rate by 2,6 % more for lung cancer, by 1,7 % for renal cancer and by 1,5 % laryngeal one.
As regards the patients with AIDS, the leukemia risk and malign cerebral tumors was higher by 8,02%, respectively 4,86 %. The risk of Hodgkin Lymphoma and lung cancer is 3 times higher for patients with AIDS than for the ones with HIV infection, while the hepatic and laryngeal cancer were also significantly higher in terms of incidence. The risk for all the types of non-AIDS cancers, associated, was 3,17 times higher for people with AIDS.
"It still remains a mist if either the HIV infected people are indeed facing a higher risk to develop non-AIDS cancer or making some combined studies without adjusting the risk factors for cancer can be responsible for this apparently increased incidence " stated the authors.
" The future cumulative projects (most likely than meta-analysis) that would compare the HIV infected people with the uninfected ones will allow throwing light on the effects that HIV has over developing the non-AIDS cancers" had concluded the researchers.
Source: Medscape , J Acquir Immun Defic Syndr 2009;52:611-622.
http://www.medscape.com/viewarticle/714483
